Related Experiment Video
Updated: Jan 13, 2026
08:44
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
6.5K
Sex Differences in Oxidative Stress Concerning Allergic Diseases
Mattia Cristallo1, Fabiana Furci2, Marco Casciaro3
1Department of Precision and Regenerative Medicine and Ionian Area, Regional Reference Center for Allergic and Immunological Diseases, University of Bari Aldo Moro, 70124 Bari, Italy.
Biomolecules
|October 29, 2025
Summary
Sexual hormones significantly impact immune responses and disease development, particularly in allergic conditions. Research explores oxidative stress biomarkers to understand sex differences in atopic diseases for precision medicine approaches.
Area of Science:
- Immunology
- Endocrinology
- Allergology
Background:
- Sexual hormones influence immune dimorphism and inflammatory responses.
- Hormonal variations affect the control of reactive oxygen and nitrogen species, and free radicals.
- Oxidative stress plays a role in the pathogenesis of various diseases.
Purpose of the Study:
- To analyze oxidative stress biomarkers in relation to sex differences in atopic diseases.
- To understand the interaction between hormones, oxidative stress, and immune responses in allergic conditions.
- To lay the foundation for precision medicine in treating atopic diseases.
Main Methods:
- Analysis of primary allergic respiratory and skin diseases.
- Investigation of biomarkers associated with oxidative stress.
- Evaluation of sex differences in disease onset and progression.
Main Results:
- Identified potential biomarkers of oxidative stress linked to sex differences in atopic diseases.
- Established the influence of hormonal variations on inflammatory and adaptive immune systems.
- Highlighted the role of oxidative stress in the interplay between hormones and atopic disease development.
Conclusions:
- Understanding sex-based differences in hormone-mediated oxidative stress is crucial for atopic disease management.
- Identifying common targets can facilitate the development of tailored therapies.
- This research supports a precision medicine approach for allergic diseases.
Keywords:
allergic contact dermatitisallergic rhinitisantioxidantasthmaatopic dermatitisgender differencesoxidative stresssex hormonesurticariaMore Related Videos
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:29Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
01:20Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
01:26Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
01:27Psychoneuroimmunology: Cardiovascular Disease
382
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
382