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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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What Is the Involvement of Gut Microbiome in the Pathophysiology of Diabetes?
Kajetan Kiełbowski1, Paulina Plewa1, Jan Zadworny1
1Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Abstract:
Diabetes mellitus (DM) encompasses a group of metabolic diseases characterised by abnormal glucose levels. The pathophysiology of DM involves intricate disruptions in glucose metabolism and immune regulation. The gut microbiome is known to play a crucial role in human health and disease, and changes in its composition have been reported in numerous conditions, including DM. In this review, we discuss recent findings on the intricate relationship between the gut microbiome and DM, including its complications. We highlight the involvement of gut microorganisms in inflammation and metabolic processes, and we summarise current evidence on how antidiabetic therapies influence microbiome composition and activity. Finally, we explore the potential role of microbiome monitoring in predicting treatment response.
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