Related Experiment Video
Updated: Jan 13, 2026
12:09
Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
Published on: August 10, 2022
7.3K
Human Blastoid: A Next-Generation Model for Reproductive Medicine?
Anfisa S Ryabchenko1, Vepa K Abdyev1, Ekaterina A Vorotelyak1
1Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.
Biology
|October 29, 2025
Summary
Synthetic embryology offers a novel way to study early human development using stem cells, creating synthetic embryo systems (SES) as alternatives to natural embryos. These blastoid models show promise for research and improving assisted reproductive technologies.
Area of Science:
- Developmental Biology
- Stem Cell Biology
- Reproductive Medicine
Background:
- Human early embryogenesis research is limited by embryo access.
- Current embryo assessment in assisted reproductive technologies (ART) is subjective.
- Animal models poorly represent human embryonic development.
Purpose of the Study:
- To explore synthetic embryology as a model for human early development.
- To evaluate synthetic embryo systems (SES) as alternatives to natural embryos.
- To discuss blastoids as models for human blastocysts.
Main Methods:
- Review of synthetic embryology approaches.
- Analysis of diploid pluripotent stem cells (PSCs) for SES creation.
- Examination of blastoid structures and their simulation capabilities.
Main Results:
- Synthetic embryo systems (SES) are created using PSCs without germ cells.
- SES offer potential for objective embryo qualification and personalized ART.
- Blastoids are human blastocyst-like structures used as research models.
Conclusions:
- Synthetic embryology and blastoids provide promising alternatives for studying early human development.
- Further modifications are needed for blastoid models to fully simulate human blastocysts.
- SES hold potential for advancing fundamental research and clinical applications in ART.
