Related Experiment Video
Updated: Jan 13, 2026
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
8.2K
Fibroblast Growth Factor-Derived Peptides: Sources, Functions, and Applications
Cheng-Kun Cao1, Zhong-Yuan Shi1, Chuan-Bang Chen2
1School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325000, China.
Bioengineering (Basel, Switzerland)
|October 29, 2025
Summary
Fibroblast growth factors (FGFs) and their derived peptides are vital for tissue repair and metabolic regulation. This review explores FGF-derived peptides
Area of Science:
- Biochemistry and Molecular Biology
- Regenerative Medicine
- Pharmacology
Background:
- Fibroblast growth factors (FGFs) are key regulators of fundamental biological processes like development, metabolism, and healing.
- FGF-derived peptides, engineered or extracted, mimic FGF functions, showing therapeutic promise.
- These peptides offer potential applications across diverse medical fields.
Purpose of the Study:
- To comprehensively review the origins and biological activities of FGF-derived peptides.
- To elucidate the molecular mechanisms underlying their therapeutic effects.
- To explore the future applications and clinical translation of FGF-derived peptides.
Main Methods:
- Literature review of existing research on FGF-derived peptides.
- Analysis of studies detailing peptide sources and functional characterization.
- Synthesis of information on molecular mechanisms and application potential.
Main Results:
- FGF-derived peptides are sourced from natural fragments or designed structures.
- They exhibit diverse bioactivities, including tissue regeneration, metabolic control, and neural repair.
- Potential applications span oncology, metabolic disorders, and drug delivery systems.
Conclusions:
- FGF-derived peptides represent a promising class of therapeutic agents.
- Further research into structural optimization and drug delivery is warranted.
- Clinical translation holds significant potential for various diseases.
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