The Impact of Stenosis Severity on Hemodynamic Parameters in the Iliac Artery: A Fluid-Structure Interaction Study

The common iliac artery supplies blood to the lower extremities, and stenosis in this region severely impacts hemodynamics. This study investigates the effects of 25%, 50%, and 75% iliac artery stenosis on key hemodynamic parameters using a fluid-structure interaction (FSI) approach. Semi-idealized geometries reconstructed from patient-specific data modeled realistic arterial behavior. Parameters such as wall displacement, time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), high oscillatory low shear magnitude (HOLMES) index, and endothelial cell activation potential (ECAP) were evaluated. Results showed peak wall displacement of 2.85 mm in the bifurcation zone under 75% stenosis. TAWSS increased with stenosis severity, peaking in stenotic regions and decreasing significantly downstream. OSI was highest in non-stenosed right branches and bifurcation areas, indicating multidirectional shear forces. HOLMES values were lowest downstream of stenoses, indicating disturbed flow. ECAP exceeded the thrombosis risk threshold (1.4 Pa^-1) in post-stenotic zones under 75% stenosis, suggesting a higher risk of clot formation. These results demonstrate that stenosis disrupts local flow and causes hemodynamic changes downstream, emphasizing the need for comprehensive clinical assessment beyond the stenotic site. Regions with elevated ECAP and low HOLMES downstream may be prone to thrombosis, highlighting the importance of careful hemodynamic monitoring for treatment strategies.