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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
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Continuous Optical Biosensing of IL-8 Cancer Biomarker Using a Multimodal Platform.

A L Hernandez1,2, K Mandal2, B Santamaria1,3,4

  • 1Group of Optics, Photonics, and Biophotonics, Center for Biomedical Technology (CTB), Universidad Politécnica de Madrid, Parque Científico y Tecnológico de la UPM, Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain.

Bioengineering (Basel, Switzerland)
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

We developed a portable biosensor for continuous detection of human interleukin 8 (IL-8), a key cancer biomarker. This device enables rapid, label-free monitoring for improved cancer prognosis and therapy evaluation.

Keywords:
continuous sensingfiber optic sensorsfluidic deviceintegrated modulelabel-freemicrophysiological systemsoptical biosensors

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Area of Science:

  • Biomedical Engineering
  • Optical Biosensing
  • Cancer Biomarker Detection

Background:

  • Human interleukin 8 (IL-8) is overexpressed in certain cancers, making it a potential biomarker for cancer prognosis and therapy evaluation.
  • Continuous monitoring of cancer biomarkers offers a non-invasive alternative to traditional diagnostic tools like imaging and immunohistology.

Purpose of the Study:

  • To engineer a compact, portable, and easy-to-assemble biosensing module for continuous, label-free detection of IL-8.
  • To demonstrate the utility of the biosensor for rapid biomolecule detection and its suitability for organ-on-a-chip systems.

Main Methods:

  • Utilized a label-free biosensor with optical readouts for IL-8 detection.
  • Integrated a fluidic chip, a biosensing chip with resonant nanopillar transducer (RNP) networks, and a fiber optics-based optical readout head.
  • Employed a polydimethyl siloxane (PDMS) microfluidic chip and an optical fiber connected to a spectrometer for signal analysis.

Main Results:

  • Successfully demonstrated anti-IL-8 immobilization and specific recognition of IL-8 via sensogram analysis.
  • Achieved continuous detection of IL-8 with a portable and easy-to-handle module.
  • The system provides biomolecule detection within minutes.

Conclusions:

  • The developed biosensing module is suitable for in-line sensing in physiological and biomimetic organ-on-a-chip systems.
  • The multiplexed design offers potential for high-throughput screening of multiple biomarkers.
  • This technology could aid in more accurate cancer diagnosis and prediction when combined with other medical data.