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Identifying Plasma Biomarkers That Predict Patient-Reported Outcomes Following Treatment for Trapeziometacarpal

Mauro Maniglio1, Moaath Saggaf2, Nupur Purohit3

  • 1Department of Hand Surgery, The Balgrist, University Clinic, 8008 Zürich, Switzerland.

International Journal of Molecular Sciences
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Two plasma biomarkers, PIIANP and Visfatin, can predict treatment outcomes for trapeziometacarpal (TM) osteoarthritis (OA). PIIANP indicates improvement, while Visfatin suggests worsening of TM OA symptoms one year post-treatment.

Keywords:
CMC-1 osteoarthritisTM osteoarthritisfirst carpometacarpal jointfirst carpometacarpal osteoarthritisosteoarthritisplasma biomarkerstrapeziometacarpal jointtrapeziometacarpal osteoarthritis

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Area of Science:

  • Orthopedics
  • Biomarker Discovery
  • Rheumatology

Background:

  • Trapeziometacarpal (TM) joint osteoarthritis (OA) is common, but specific biomarkers for hand OA are scarce.
  • Identifying predictive biomarkers for TM OA treatment response is crucial for personalized medicine.

Purpose of the Study:

  • To identify systemic plasma biomarkers at baseline associated with patient-reported outcomes one year after TM OA treatment.
  • To explore the predictive value of biomarkers related to cartilage turnover, bone remodeling, pain, and lipid metabolism.

Main Methods:

  • Prospective study of 143 TM OA patients undergoing conservative therapy, fat grafting, or surgery.
  • Supervised machine learning (Lasso regularization) and generalized estimating equation models analyzed 10 systemic biomarkers.
  • One-year follow-up assessed patient-reported outcomes (VAS, QuickDASH, TASD).

Main Results:

  • Machine learning identified associations between outcomes and biomarkers including PIIANP, Visfatin, adiponectin, and leptin.
  • Baseline PIIANP was associated with improvements in VAS, QuickDASH, and TASD scores.
  • Baseline Visfatin was associated with worsening VAS scores at one year.

Conclusions:

  • Systemic plasma biomarkers PIIANP and Visfatin show potential for predicting clinical outcomes in TM OA treatment.
  • PIIANP may predict treatment improvement, whereas Visfatin may predict worsening of TM OA.
  • Further prospective studies are warranted to validate these predictive biomarkers.