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Targeted Inhibition in Pediatric MET and ALK-Altered Hemispheric Gliomas: Objective Responses Followed by Treatment

David Wilson1,2,3, Sateesh Jayappa3,4, Lora Parker3

  • 1Department of Pediatrics, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72223, USA.

International Journal of Molecular Sciences
|October 29, 2025
PubMed
Summary

Pediatric high-grade gliomas (pHGGs) with targetable gene alterations can initially respond to targeted therapies. However, resistance often develops, necessitating further molecular analysis for effective treatment adjustments.

Keywords:
ALK alterationMET alterationbrain tumorgliomapediatric CNS tumorpediatric high-grade glioma

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