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Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

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In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos
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Jumping Translocation Breakpoint Expression in Midgestation Mouse Embryos.

Carley McGrath1, Taniya M Jayaweera2, Thomas Lufkin1

  • 1Department of Biology, Clarkson University, Potsdam, NY 13699, USA.

International Journal of Molecular Sciences
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Jumping translocations (JTs) can cause partial trisomies. This study found the Jumping Translocation Breakpoint (JTB) gene is not in the Epidermal Differentiation Complex, suggesting its role in cancer may be unrelated to its previously assumed location.

Keywords:
Epidermal Differentiation Complex (EDC)Jumping Translocation Breakpoint (JTB)Prostate Androgen-Regulated (PAR)human 1q21jumping translocations (JTs)mouse embryomurine 3q

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Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • Jumping translocations (JTs) can result in partial trisomies, frequently observed in cancer.
  • A breakpoint within the Jumping Translocation Breakpoint (JTB) gene has been linked to JTs involving chromosome 1q.
  • Previous research mapped JTB to the Epidermal Differentiation Complex (EDC) at 1q21, focusing on its role in malignant tissues.

Purpose of the Study:

  • To refine the genomic mapping of the JTB gene.
  • To investigate the expression pattern of JTB in developing tissues.
  • To determine if the oncogenic potential of JTB translocations is linked to its location within the EDC.

Main Methods:

  • Utilized updated genomic data for precise JTB gene mapping.
  • Employed RNA in situ hybridization (RISH) to visualize JTB expression.
  • Examined expression patterns in midgestational wild-type mouse embryos.

Main Results:

  • Human JTB and murine Jtb genes are located outside the EDC.
  • Jtb expression was observed in multiple embryonic tissues, including the heart and vertebral column.
  • Jtb expression partially overlapped with early neural crest cell lineage markers.

Conclusions:

  • The oncogenic potential of JTB translocations is likely independent of its previously assumed location within the EDC.
  • JTB's expression in developing tissues suggests roles beyond its association with cancer.
  • Re-evaluation of JTB's genomic location and expression is crucial for understanding its function.