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Therapeutic Potential and Cancer Cell Death-Inducing Effects of Apigenin and Its Derivatives

Pritam Bhagwan Bhosale1, Se Hyo Jeong1, Hun Hwan Kim1

  • 1Department of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of Korea.

International Journal of Molecular Sciences
|October 29, 2025
PubMed

Insights

Flavonoids, like apigenin and its derivatives, show promise in cancer prevention and treatment. These natural compounds exhibit anticancer activity by promoting apoptosis and autophagy in preclinical studies.

Area of Science:

  • Oncology
  • Nutritional Science
  • Pharmacology

Background:

  • Cancer is a major global health concern, prompting research into natural compounds for prevention and therapy.
  • Flavonoids are natural dietary compounds increasingly studied for their potential role in reducing cancer risk.
  • Preclinical research indicates flavonoids modulate key cancer mechanisms like inflammation, angiogenesis, and oxidative stress.

Purpose of the Study:

  • To review the therapeutic potential of apigenin and its related forms in cancer.
  • To explore the biological effects and anticancer properties of apigenin, vitexin, and apigetrin.
  • To summarize evidence for flavonoid-induced cancer prevention and treatment strategies.

Main Methods:

  • Review of preclinical (cell-based and animal) studies on flavonoids and cancer.
  • Analysis of research on the mechanisms of action of apigenin, vitexin, and apigetrin.
  • Examination of biological effects including antioxidant, anti-inflammatory, and anti-tumor properties.

Main Results:

  • Apigenin, vitexin, and apigetrin demonstrate significant anticancer activity in preclinical models.
  • These flavonoids exhibit protective effects against cancer development.
  • Mechanisms include the promotion of apoptosis (programmed cell death) and autophagy (cellular self-cleaning).

Conclusions:

  • Flavonoids like apigenin, vitexin, and apigetrin show promise as natural agents for cancer prevention and treatment.
  • Their ability to modulate cancer cell mechanisms offers potential therapeutic strategies.
  • Further research into these compounds could inform dietary and therapeutic approaches to cancer management.
Keywords:
anti-inflammatoryanticancerapigeninapigetrinflavonoidsvitexin

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