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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Does Genetic Variation in Detoxification Capacity Influence Hepatic Biomarker Responses to a Liver Support

Markus Schauer1,2, Susanne Mair2, Michael Keiner1

  • 1Department of Sport Science, German University of Health & Sport (DHGS), 85737 Ismaning, Germany.

International Journal of Molecular Sciences
|October 29, 2025
PubMed
Summary

Liver support supplements improved detoxification biomarkers and reduced weight and BMI in adults. These positive effects on detoxification pathways were observed regardless of genetic variations in detoxification capacity.

Keywords:
N-acetylcysteinegenetic predispositionglucuronidationglutathionehepatic metabolismnutrigenomicsoxidative stressprecision nutritionredox balanceα-lipoic acid

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