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SUMF1 Common Variant rs793391 Is Associated with Response to Inhaled Corticosteroids in Patients with COPD

Charikleia Ntenti1,2, Eleni Papakonstantinou1, Leticia Grize1

  • 1Clinic of Respiratory Medicine, University of Freiburg, Faculty of Medicine, University of Freiburg, 79098 Freiburg im Breisgau, Germany.

International Journal of Molecular Sciences
|October 29, 2025
PubMed
Summary

Specific gene variants in sulfatase modifying factor-1 (SUMF1) may predict chronic obstructive pulmonary disease (COPD) progression and response to inhaled corticosteroids (ICS). The rs793391 SNP showed improved lung function with ICS treatment.

Keywords:
COPD pharmacogeneticsinhaled corticosteroidspersonalized therapyprecision medicinesingle nucleotide polymorphismsulfatase modifying factor 1sulfatases

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