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DeepSnap: From Three-Dimensional Molecular Images to Quantitative Structure-Activity Predictions.

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Steroid-Induced Thrombosis: A Comprehensive Analysis Using the FAERS Database.

Ayame Watanabe1, Yoshihiro Uesawa1

  • 1Department of Medical Molecular Informatics, Meiji Pharmaceutical University, Tokyo 204-8588, Japan.

Pharmaceuticals (Basel, Switzerland)
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Steroid drugs, particularly sex hormones, increase the risk of thrombosis, including venous thrombosis and large-vessel occlusions. Understanding these risks aids in safer steroid drug selection for at-risk patients.

Keywords:
FAERS databasearterial thrombosispharmacovigilancesex hormonessteroidsvenous thromboembolism

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Area of Science:

  • Pharmacology
  • Thrombosis Research
  • Drug Safety

Background:

  • Steroid drugs can induce thrombosis, a condition with severe consequences like heart attack and stroke.
  • Existing knowledge on steroid-induced thrombosis mechanisms and differing risks is limited.

Purpose of the Study:

  • To investigate the relationship between various steroid drug classes and thrombosis risk.
  • To identify specific steroid types with a higher propensity for causing thrombotic events.

Main Methods:

  • Utilized the U.S. Food and Drug Administration Adverse Event Reporting System (2004-2024).
  • Extracted demographic, drug, and adverse event data.
  • Characterized steroids by physiological function, receptor specificity, and Anatomic Therapeutic Chemical classification.

Main Results:

  • Sex hormones (androgens, progestogens, estrogens) showed a high potential for thrombotic events.
  • Sex hormone preparations were linked to increased venous thrombosis risk via statistical analysis.
  • Cardiovascular medications and mineralocorticoids were associated with large-vessel occlusions.

Conclusions:

  • Findings highlight specific steroid drug classes associated with distinct thrombotic risks.
  • This information can guide clinical decisions for selecting safer steroid therapies in vulnerable patients.