Related Experiment Video
Updated: Jan 13, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
1.5K
Solidification Materials and Technology for Solid Self-Emulsifying Drug Delivery Systems.
1College of Pharmacy, Hanyang University, Ansan 15588, Republic of Korea.
Pharmaceuticals (Basel, Switzerland)
|October 29, 2025
Summary
Solid self-emulsifying drug delivery systems (SEDDS) overcome liquid formulation challenges. This review details solid carriers and techniques for stable, versatile solid SEDDS with improved bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Low aqueous solubility of drug candidates hinders oral drug development.
- Liquid self-emulsifying drug delivery systems (SEDDS) offer a solution but face stability and manufacturing issues.
- Solid SEDDS are being developed to address these limitations.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in solid SEDDS.
- To analyze the roles of solid carriers and solidification techniques in solid SEDDS.
- To explore applications, commercial challenges, and future perspectives of solid SEDDS.
Main Methods:
- Review of literature on solid carriers (mesoporous silica, polymers, carbon, etc.) and their properties.
- Analysis of various solidification techniques (spray drying, hot melt extrusion, adsorption, 3D printing).
- Examination of applications like controlled release, mucoadhesion, and targeted delivery.
Main Results:
- Physicochemical properties of carriers significantly influence drug loading, release kinetics, and in vivo performance.
- Solidification methods impact the final product's quality and scalability.
- Solid SEDDS offer enhanced stability, bioavailability, and functional versatility.
Conclusions:
- Solid SEDDS represent a promising approach to overcome challenges in oral drug delivery.
- Careful selection of carriers and solidification techniques is crucial for high-performance solid SEDDS.
- Further research and development are needed to address commercial challenges and unlock the full potential of solid SEDDS.
More Related Videos
Related Concept Videos
01:16Bioavailability Enhancement: Drug Solubility Enhancement
212
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
212
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
392
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
392
01:27Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
146
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
146
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
193
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
193
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.6K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.6K
01:17In Vitro Drug Dissolution: Alternative Methods
190
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
190