RETRACTED: Poma et al. In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R. Pharmaceuticals 2021, 14, 111
- 1Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.
- 2Department of Plant Biology and Ecology, University of Antananarivo, P.O. Box 906, Antananarivo 101, Madagascar.
- 0Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study investigated the effects of Euphorbia intisy essential oil on P-glycoprotein activity in acute myeloid leukemia cells. The findings are no longer available due to article retraction.
Area Of Science
- Pharmacology
- Cancer Biology
- Natural Products
Background
- P-glycoprotein (P-gp) is a key efflux pump implicated in multidrug resistance (MDR) in cancer.
- Acute Myeloid Leukemia (AML) often exhibits resistance to chemotherapy due to factors like P-gp overexpression.
- Natural products are explored for novel therapeutic strategies against resistant cancers.
Purpose Of The Study
- To evaluate the in vitro impact of *Euphorbia intisy* essential oil on P-glycoprotein activity.
- To assess the potential of this natural compound in overcoming drug resistance in AML cell lines.
Main Methods
- The study utilized the HL-60R cell line, a P-glycoprotein-overexpressing variant of acute myeloid leukemia.
- In vitro assays were performed to measure P-glycoprotein activity and cellular responses to the essential oil.
Main Results
- The article reporting these results has been retracted.
- Specific findings regarding the modulation of P-glycoprotein activity by *Euphorbia intisy* essential oil are unavailable.
Conclusions
- Due to the retraction, no conclusions can be drawn from the reported study.
- The scientific record regarding *Euphorbia intisy* essential oil and P-glycoprotein activity in AML remains incomplete.
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.