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Fabrication and Characterization of Curcumin-Complexed Nanoparticles Using Coconut Protein Nanoparticles.

Leila Ziaeifar1, Maryam Salami1,2,3, Gholamreza Askari1

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Pharmaceutics
|October 29, 2025
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Summary

Coconut protein nanoparticles effectively encapsulate curcumin, enhancing its antioxidant activity and solubility. This novel nano-delivery system shows potential for functional foods due to controlled release properties.

Keywords:
antioxidant activitycoconut proteincomplexationnanoparticlerelease kinetic

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Area of Science:

  • Food Science
  • Nanotechnology
  • Biochemistry

Background:

  • Curcumin exhibits diverse biological activities but faces challenges in food applications due to poor solubility, degradation, and low bioavailability.
  • Nanostructure delivery systems offer solutions for enhanced bioavailability and controlled release of bioactive compounds.

Purpose of the Study:

  • To develop coconut protein nanoparticles (CPNPs) as a delivery system for curcumin (Cur).
  • To evaluate the encapsulation efficiency, antioxidant activity, and controlled release of curcumin-loaded CPNPs.

Main Methods:

  • CPNPs were fabricated via heat treatment at 85°C and pH 2.
  • Curcumin was encapsulated into CPNPs, and its properties were analyzed using SEM, FTIR, and X-ray diffraction.
  • Antioxidant activity was assessed using the ABTS radical scavenging method, and release kinetics were studied in a simulated gastrointestinal tract.

Main Results:

  • CPNP-Cur exhibited high encapsulation efficiency (96.6%) and loading capacity (19.32 µg/mg protein).
  • SEM revealed spherical CPNPs with an average size of 80 nm.
  • Encapsulation significantly enhanced curcumin's antioxidant activity and demonstrated sustained release (29.2% cumulative release after 4 hours).

Conclusions:

  • Coconut protein nanoparticles are a promising nanocarrier for curcumin.
  • CPNP-Cur demonstrates improved antioxidant properties and controlled release, making it suitable for functional food development.