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Next-Generation Natural Hydrogels in Oral Tissue Engineering.
Mariana Chelu1, Monica Popa1, José María Calderón Moreno1
1"Ilie Murgulescu" Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania.
Pharmaceutics
|October 29, 2025
Summary
Natural polymer hydrogels enriched with bioactive agents show great promise for oral tissue regeneration. These advanced biomaterials support cell growth and healing while fighting inflammation and infection in the mouth.
Area of Science:
- Biomaterials Science
- Regenerative Dentistry
- Tissue Engineering
Background:
- Hydrogels are ideal biomaterials for oral tissue regeneration due to their water content, biocompatibility, and ability to mimic native environments.
- Natural polymer-based hydrogels (e.g., chitosan, alginate, collagen) offer biodegradability, bioactivity, and extracellular matrix-like properties, crucial for oral tissue repair.
- Recent advancements have enabled hydrogels to support regeneration of diverse oral tissues, including periodontal tissues, bone, mucosa, pulp, and dentin.
Purpose of the Study:
- To review the design, material selection, and functional properties of natural polymer-based hydrogels for oral tissue regeneration.
- To explore the integration of bioactive factors (essential oils, cells, growth factors) to enhance hydrogel functionality.
- To highlight the applications of these advanced hydrogels in periodontal therapy, guided tissue regeneration, and dental implant integration.
Main Methods:
- Comprehensive literature review focusing on natural polymer hydrogels and bioactive agents in oral regeneration.
- Analysis of hydrogel design strategies, material properties, and incorporation of functional components.
- Evaluation of biomedical applications and clinical translation potential in regenerative dentistry.
Main Results:
- Biopolymer hydrogels enriched with bioactive molecules exhibit antimicrobial, anti-inflammatory, and antioxidant properties, crucial for the oral environment.
- These multifunctional hydrogels effectively promote regeneration of various oral tissues, addressing challenges in periodontal disease and bone defects.
- The review highlights successful applications in guided tissue regeneration and enhancing dental implant integration.
Conclusions:
- Natural polymer-based hydrogels with bioactive enrichment represent a promising strategy for advancing regenerative dentistry.
- Addressing challenges in mechanical stability, degradation, and clinical translation is key for future optimization.
- These next-generation hydrogel systems hold significant potential for improving outcomes in oral tissue regeneration.
