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The Application of Novel Drug Delivery Systems in the Treatment of Osteoarthritis

Pengfei Huang1, Junjie Zhao1, Xiyu Wang1

  • 1The First Clinical College of Medicine, Lanzhou University, Lanzhou 730000, China.

Pharmaceutics
|October 29, 2025
PubMed

Insights

Novel drug delivery systems offer targeted osteoarthritis (OA) treatment, improving drug efficacy and reducing side effects. Further research into biocompatibility and personalized approaches is needed for clinical application.

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Orthopedics

Background:

  • Osteoarthritis (OA) is a degenerative joint disease impacting cartilage, synovium, and bone.
  • Current OA treatments (NSAIDs, corticosteroids, hyaluronic acid) offer symptomatic relief but have limitations and side effects.
  • Novel drug delivery systems (NDDS) are being explored to overcome these limitations.

Purpose of the Study:

  • To review the potential of NDDS for osteoarthritis treatment.
  • To highlight the advantages of NDDS over conventional therapies.
  • To identify challenges and future directions for NDDS in OA management.

Main Methods:

  • Review of current literature on NDDS for OA.
  • Analysis of various NDDS platforms (liposomes, nanoparticles, hydrogels, etc.).
  • Evaluation of controlled drug release mechanisms for anti-inflammatory, antioxidant, and gene therapies.

Main Results:

  • NDDS enhance drug targeting, prolong retention, and reduce systemic toxicity in OA models.
  • Controlled release from NDDS improves therapeutic outcomes by delivering active agents effectively.
  • Various NDDS platforms show promise for delivering diverse therapeutic agents for OA.

Conclusions:

  • NDDS represent a promising strategy for advanced osteoarthritis treatment.
  • Overcoming challenges in biocompatibility, scalability, and clinical translation is crucial.
  • Future research should focus on material optimization and personalized medicine for NDDS in OA.
Keywords:
delivery systemnanoparticlesosteoarthritis

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