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A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

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Design of Polycation-Functionalized Resveratrol Nanocrystals for Intranasal Administration.

Angela Bonaccorso^1,2,3, Elide Zingale^1,2, Giuseppe Caruso^4,5

¹Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.

|October 29, 2025

Summary

Surface-modified resveratrol nanocrystals (RSV NCs) were developed for enhanced brain delivery. Functionalized RSV NCs show potential for treating neurodegenerative diseases via intranasal administration.

Keywords:

cell viability nanotechnology natural compound nose-to-brain quality by design

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

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Published on: August 31, 2019

Area of Science:

Nanotechnology
Materials Science
Neuroscience

Background:

Nanocrystals (NCs) offer a versatile platform for drug delivery and precision medicine.
Surface modification of NCs enhances targeted delivery potential.
Resveratrol (RSV) possesses antioxidant and neuroprotective properties relevant for neurological disorders.

Purpose of the Study:

To design and surface-functionalize resveratrol nanocrystals (RSV NCs) for improved brain delivery.
To evaluate the potential of functionalized RSV NCs for intranasal administration.
To assess the suitability of RSV NCs for therapeutic applications in neurodegenerative diseases.

Main Methods:

Resveratrol nanocrystals (RSV NCs) were designed using the Quality by Design approach.
RSV NCs were functionalized with poly-l-arginine hydrochloride for intranasal delivery.
Characterization included mucoadhesion, stability in artificial cerebrospinal fluid, crystallinity, solubility, and scavenging activity (DPPH assay).

Main Results:

Successfully designed truncated cubic RSV NCs (~240 nm) with ~80% drug content.
Functionalization with poly-l-arginine hydrochloride yielded a positively charged nanosuspension.
Nanonization improved RSV solubility and maintained scavenging activity; nanosuspensions showed suitable properties for intranasal administration and were safe in HMC3 cells.

Conclusions:

Functionalized RSV NCs demonstrate enhanced brain delivery potential.
This platform holds promise for improving therapeutic outcomes in neurodegenerative diseases.
Intranasal administration of functionalized RSV NCs is a viable strategy for brain targeting.