Lipedema and Hypermobility Spectrum Disorders Sharing Pathophysiology: A Cross-Sectional Observational Study.

Area of Science:

• Connective tissue disorders
• Systemic diseases
• Lipedema pathophysiology

Background:

• Lipedema is an underdiagnosed chronic condition affecting subcutaneous fat, causing inflammation, pain, and edema.
• A potential overlap exists between lipedema and hypermobility spectrum disorders (HSD), both linked to connective tissue dysfunction.
• This study investigates shared features between lipedema and HSD to improve diagnosis and treatment.

Purpose of the Study:

• To explore pathophysiological links between lipedema and HSD.
• To identify clinical correlations and comorbidities.
• To advocate for integrated diagnostic and therapeutic strategies.

Main Methods:

• A cross-sectional observational study using an online survey.
• Participants included individuals with lipedema and a control group with lymphedema.
• Survey assessed HSD-related symptoms across various body systems.

Main Results:

• 44% of lipedema patients reported joint hypermobility, with 60% recalling childhood hypermobility.
• High rates of pediatric overweight (50%), low muscle tone (55%), and fatigue (70%) were noted in lipedema patients.
• Lipedema patients exhibited more connective tissue-related motor deficits and systemic symptoms than the control group.

Conclusions:

• Connective tissue laxity may be central to lipedema pathogenesis, causing multisystemic issues.
• The high prevalence of HSD-like features indicates lipedema is a systemic disorder.
• Early identification of connective tissue issues in children could allow timely interventions and disease mitigation.