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Related Concept Videos

Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

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The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
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Adrenal Gland Disorders01:27

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Related Experiment Video

Updated: Jan 13, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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Multivisceral Resection for Suspected Adrenocortical Carcinoma.

Agata Dukaczewska1, Peer I Gottschalkson1, Wenzel Schoening1

  • 1Department of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Journal of Clinical Medicine
|October 29, 2025
PubMed
Summary

Multivisceral resection for adrenocortical carcinoma (ACC) is safe and feasible in specialized centers. This approach achieves comparable oncologic outcomes to isolated adrenalectomy, even for advanced ACC cases requiring complete tumor resection.

Keywords:
adrenalectomyadrenocortical carcinomalymphadenectomymultivisceral resection

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Area of Science:

  • Surgical Oncology
  • Adrenal Gland Neoplasms
  • Oncology

Background:

  • Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy.
  • Complete tumor resection (R0) is crucial for prognosis.
  • Multivisceral resection may be necessary for locally advanced ACC, but outcomes data are limited.

Purpose of the Study:

  • To evaluate perioperative and oncologic outcomes of multivisceral resection for suspected ACC.
  • To compare outcomes between patients undergoing multivisceral resection and isolated adrenalectomy for ACC.

Main Methods:

  • Retrospective analysis of 21 patients undergoing multivisceral resection for suspected ACC.
  • Comparison of 18 confirmed ACC patients with 19 patients undergoing isolated adrenalectomy.
  • Analysis of perioperative data, complication rates, resection status, and survival.

Main Results:

  • Multivisceral resection patients had younger age, larger, and more advanced tumors (ENSAT).
  • Longer operative times, ICU admission, and hospital stays were noted for multivisceral resections.
  • No significant differences in complication rates, resection status, or survival between groups.

Conclusions:

  • Multivisceral resection is a safe and feasible approach for ACC in specialized centers.
  • It can achieve oncologic outcomes comparable to isolated adrenalectomy.
  • Consider multivisceral resection when R0 resection is required and technically feasible for advanced ACC.