Multivisceral Resection for Suspected Adrenocortical Carcinoma

Area of Science:

• Surgical Oncology
• Adrenal Gland Neoplasms
• Oncology

Background:

• Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy.
• Complete tumor resection (R0) is crucial for prognosis.
• Multivisceral resection may be necessary for locally advanced ACC, but outcomes data are limited.

Purpose of the Study:

• To evaluate perioperative and oncologic outcomes of multivisceral resection for suspected ACC.
• To compare outcomes between patients undergoing multivisceral resection and isolated adrenalectomy for ACC.

Main Methods:

• Retrospective analysis of 21 patients undergoing multivisceral resection for suspected ACC.
• Comparison of 18 confirmed ACC patients with 19 patients undergoing isolated adrenalectomy.
• Analysis of perioperative data, complication rates, resection status, and survival.

Main Results:

• Multivisceral resection patients had younger age, larger, and more advanced tumors (ENSAT).
• Longer operative times, ICU admission, and hospital stays were noted for multivisceral resections.
• No significant differences in complication rates, resection status, or survival between groups.

Conclusions:

• Multivisceral resection is a safe and feasible approach for ACC in specialized centers.
• It can achieve oncologic outcomes comparable to isolated adrenalectomy.
• Consider multivisceral resection when R0 resection is required and technically feasible for advanced ACC.