Related Experiment Video
Updated: Jan 13, 2026

On-site DNA Detection of Trypanosomatid Parasites and Nosema ceranae Through Alkaline Lysis Coupled to RPA/CRISPR/Cas12a System
Published on: July 18, 2025
Exploring Eco-Friendly Microbial Strategies for Nosemosis Control in Honeybee
Bogdan Tache1,2, Roxana Spulber1, Laura-Dorina Dinu2
1Research and Development Institute for Apiculture, 013975 Bucharest, Romania.
Abstract:
Nosemosis is an intestinal infection caused by intracellular fungal organisms from the Vairimorpha (formerly Nosema) group, which seriously harms honeybee colonies and is a factor in their worldwide decline. With the ban on fumagillin use in European apiculture and the limitations of conventional treatments, it is essential to identify sustainable alternative solutions. This study presents new environmentally friendly microbe-based strategies to prevent and treat infection, focusing on probiotics, postbiotics, synbiotics, and mixes with plant extracts, as well as suggesting a new approach for the future. This review discusses the latest results based on using beneficial bacteria (e.g., Lactobacillus and Enterococcus faecium) and their byproducts to decrease the spore levels and modulate the gut bacteria pattern. Moreover, innovative approaches, such as genetically engineered gut bacteria to target pathogen gene expression through RNA interference, have been mentioned. Although results vary depending on microbial strain, delivery method, season, and ecological context, microbial treatments represent a promising, safe, and adaptable alternative for modern apiculture. The paper is necessary to validate these strategies' real-world efficacy and to develop standardized microbial formulations suitable for practical implementation by beekeepers.
Insights
Sustainable microbial treatments offer a promising alternative for managing Nosemosis, an intestinal fungal infection harming honeybee colonies. These strategies, including probiotics and innovative genetic approaches, aim to protect bees where conventional treatments are limited.
Area of Science:
- Apiculture
- Microbiology
- Animal Pathology
Background:
- Nosemosis, caused by Vairimorpha fungi, severely impacts honeybee colonies globally.
- Bans on fumagillin and limited conventional treatments necessitate sustainable alternatives for honeybee health.
Purpose of the Study:
- To review environmentally friendly, microbe-based strategies for preventing and treating honeybee Nosemosis.
- To explore probiotics, postbiotics, synbiotics, plant extracts, and novel genetic approaches.
Main Methods:
- Literature review of current research on microbial interventions for Nosemosis.
- Analysis of studies using beneficial bacteria (e.g., Lactobacillus) and their byproducts.
- Inclusion of innovative methods like RNA interference via engineered gut bacteria.
Main Results:
- Microbial treatments show potential in reducing Vairimorpha spore levels.
- Beneficial bacteria can modulate honeybee gut microbiota patterns.
- Varied efficacy of treatments depends on microbial strain, delivery, and environmental factors.
Conclusions:
- Microbial strategies represent a promising, safe, and adaptable alternative for apiculture.
- Further research is needed to validate real-world efficacy and standardize microbial formulations for beekeepers.
Related Concept Videos
Biological Methods for Microbial Control
Environmental Applications of Microorganisms
Bioremediation
Chemical Agents for Microbial Control

