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Published on: March 9, 2018
Eremophilane-Type Sesquiterpenoids from Fungus Aspergillus aurantiobrunneus
Xueying Deng1, Mengsha Wei1, Yuyi Zheng1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Abstract:
Six previously undescribed sesquiterpenoids, aurantiophilanes A-F (1-6), along with six identified analogues (7-12), were isolated from the fungus Aspergillus aurantiobrunneus. Among these, compounds 1 and 3 were identified as highly oxygenated eremophilane sesquiterpenoids, with compound 1 featuring a rare ketone functional group at C-1. The structures of all compounds were unambiguously elucidated using comprehensive spectroscopic analyses, including HRESIMS, NMR, and UV spectroscopy, supplemented by electronic circular dichroism (ECD) analyses and single-crystal X-ray diffraction. All identified compounds were evaluated for immunosuppressive activity; none showed significant effects at concentrations up to 40 µM.
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