Inter-Organ Crosstalk in Neurodegenerative Disease

Area of Science:

• Neuroscience
• Immunology
• Metabolic Science

Background:

• Neurodegenerative diseases (ND) involve complex inter-organ communication.
• The gut-brain, neuro-immune, and muscle-brain axes are critical pathways.

Purpose of the Study:

• To review bidirectional interactions between the brain and peripheral organs in ND pathogenesis.
• To explore the roles of the gut microbiome, adipose tissue, and muscle-derived myokines.

Main Methods:

• Literature review of inter-organ communication in neurodegeneration.
• Analysis of pathways involving the gut, immune system, liver, and muscle.

Main Results:

• Bidirectional signaling influences neuroinflammation, protein misfolding, and neuronal dysfunction.
• Dysregulation of these axes contributes to systemic manifestations of ND.

Conclusions:

• Inter-organ pathways offer potential biomarkers and therapeutic targets for ND.
• Targeting these axes may lead to novel prevention, diagnosis, and treatment strategies.