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Prescribing LAIs: from completing the first injection to going steady.
Andrew Cutler1,2, Meghan Grady2, Alison Holladay
1Department of Psychiatry, https://ror.org/040kfrw16SUNY Upstate Medical University, Syracuse, NY, USA.
Improving adherence to antipsychotic treatment for schizophrenia patients is crucial. Long-acting injectable (LAI) antipsychotics offer a strategy to reduce relapse risk, with this guide detailing conversion and maintenance.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Medicine
Background:
- Non-adherence to antipsychotic medication is a significant factor in schizophrenia relapse.
- Long-acting injectable (LAI) antipsychotics represent a key strategy to improve treatment adherence.
- Various LAI formulations exist, necessitating clear guidance on their use.
Purpose of the Study:
- To provide a practical guide for converting patients from oral antipsychotics to LAI formulations.
- To outline evidence-based principles for the maintenance treatment with LAI antipsychotics.
- To consolidate information on available LAI antipsychotic options.
Main Methods:
- Review of available LAI antipsychotic formulations.
- Guidance on initiation and conversion strategies from oral to LAI antipsychotics.
- Principles for ongoing maintenance therapy with LAI antipsychotics.
Main Results:
- Detailed information on different LAI antipsychotic formulations and their administration schedules.
- Practical steps for transitioning patients to LAI therapy.
- Established principles for effective long-term maintenance treatment.
Conclusions:
- Conversion to LAI antipsychotics can improve adherence and potentially reduce schizophrenia relapse.
- Understanding formulation-specific details is essential for successful LAI implementation.
- This guide supports clinicians in optimizing antipsychotic treatment strategies.
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