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Assessing the Risk of Peripheral Neuropathy Among Male Tobacco Smokers With Type 2 Diabetes: A Matched Case-Control
Sana Bader1, Sanah Hasan2,3, Rakibul M Islam1
1School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Journal of Primary Care & Community Health
|October 29, 2025
Summary
Tobacco smoking significantly increases the risk of diabetic peripheral neuropathy (DPN) in men with type 2 diabetes. This highlights the urgent need for smoking cessation programs to prevent DPN.
Area of Science:
- Endocrinology
- Neurology
- Public Health
Background:
- Rising rates of diabetic complications and tobacco use globally.
- Type 2 diabetes and its associated neuropathy pose significant health challenges.
- Diabetic peripheral neuropathy (DPN) is a common and debilitating complication.
Purpose of the Study:
- To investigate the link between tobacco smoking and DPN in male patients with type 2 diabetes.
- To assess the risk of DPN associated with current and past smoking behaviors.
- To provide evidence for targeted public health interventions in the UAE.
Main Methods:
- Matched case-control study design.
- Recruitment of 140 male cases with DPN and type 2 diabetes, matched with 140 controls.
- Data collection included sociodemographics, smoking status, and clinical data.
Main Results:
- Cases with DPN were more likely to be current or past smokers.
- A longer duration of smoking was observed in cases compared to controls.
- Adjusted analysis showed a significant association between past smoking (OR=4.10) and current smoking (OR=2.48) and DPN.
Conclusions:
- Tobacco consumption is significantly associated with DPN in males with type 2 diabetes in the UAE.
- Smoking cessation interventions are crucial for managing and preventing DPN.
- Public health strategies should address tobacco use to mitigate diabetic complications.
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