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Updated: Jan 13, 2026

Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
A m-quaterphenyl probe for absolute configurational assignments of primary and secondary amines
Yuka Takeuchi1, Mutsumi Kobayashi1, Yuuka Gotoh1
1Department of Chemistry, Faculty of Science Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Abstract:
We report a method for determining the absolute configurations of chiral amino alcohols, amino acid esters, and secondary amines through the combined use of a m-quaterphenyl probe 1 and theoretical calculations. The probe 1 is covalently attached to chiral amines to form conjugates that exhibit exciton-coupled circular dichroism (ECCD) in the m-quaterphenyl chromophores. The calculated ratios of the P and M conformers, obtained via DFT calculations, show a correlation with both the sign and intensity of the experimentally observed CD spectra.
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