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RNA Splicing01:32

RNA Splicing

60.3K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.3K
Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Pre-mRNA Processing: RNA Splicing01:36

Pre-mRNA Processing: RNA Splicing

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mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

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mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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Related Experiment Video

Updated: Jan 13, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

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Transcript diversity in aging: cryptic transcription and splicing.

Brenna S McCauley1, Nicholas Nikoloutsos2, Weiwei Dang1,3

  • 1Huffington Center on Aging, Houston, TX, USA.

Medical Review (2021)
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Transcript diversity, driven by alternative splicing and cryptic transcription, increases with age. This novel transcript increase contributes to aging phenotypes and impacts tissue function.

Keywords:
agingalternative splicingcryptic transcriptionepigenetics

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gerontology

Background:

  • Transcriptome remodeling is a hallmark of aging.
  • Alternative splicing and cryptic transcription contribute to transcript diversity.
  • Novel transcripts increase with age in various tissues.

Purpose of the Study:

  • To investigate the role of increased transcript diversity in aging.
  • To explore the functional implications of age-associated transcript changes.

Main Methods:

  • Analysis of age-associated transcriptome remodeling.
  • Identification of novel transcripts through alternative splicing and cryptic transcription.

Main Results:

  • Structurally novel transcripts significantly increase during aging.
  • Genes with age-associated cryptic and alternatively spliced transcripts are linked to aging phenotypes.
  • These include cognitive decline, reduced muscle strength, and immune aging.

Conclusions:

  • Increased transcript diversity via alternative splicing and cryptic transcription is a potent driver of aging.
  • These findings add a new layer to understanding the transcriptional regulation of aging.