Bronchiectasis and sinonasal diseases: a narrative review

Area of Science:

• Respiratory Medicine
• Immunology

Background:

• Bronchiectasis and chronic rhinosinusitis are chronic upper and lower airway diseases involving infection and inflammation.
• These conditions share clinical, radiological, and pathophysiological similarities, potentially driven by neutrophil or eosinophil inflammation.
• The prevalence and pathogenetic relationship of their coexistence are not well-established.

Purpose of the Study:

• To explore the association between bronchiectasis and chronic rhinosinusitis.
• To understand the implications of this comorbidity on disease burden and patient outcomes.

Main Methods:

• Literature review and analysis of existing studies on bronchiectasis and chronic rhinosinusitis.
• Investigation of shared etiological factors and inflammatory pathways.

Main Results:

• Evidence suggests patients with both conditions may experience increased exacerbations, symptom severity, radiological findings, and reduced quality of life.
• The precise prevalence and causal links require further investigation in diverse populations.

Conclusions:

• The coexistence of bronchiectasis and chronic rhinosinusitis may signify a more severe disease phenotype.
• Identifying treatable traits and implementing a multidisciplinary care model involving various specialists is essential for optimal patient management.