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Beyond the Bruise: Unmasking Disseminated Intravascular Coagulation in Alcohol-Related Presentations
Sri Amarnath Mathiyalagan1, Aemon Fatima1, Syeda Safa Sadiya1
1Emergency Medicine, Barking, Havering and RedBridge University Hospitals National Health Service (NHS) Trust, London, GBR.
Insights
Disseminated intravascular coagulation (DIC) is a critical condition in patients with liver disease. Early recognition of DIC in cirrhotic patients presenting to the emergency department is vital for timely intervention and improved outcomes.
Area of Science:
- Internal Medicine
- Emergency Medicine
- Hepatology
Background:
- Disseminated intravascular coagulation (DIC) is a severe complication characterized by systemic coagulation activation, leading to thrombosis and bleeding.
- Patients with chronic liver disease, such as alcohol-related cirrhosis and autoimmune hepatitis, are at increased risk for developing DIC.
- Emergency department presentations can be complex, with factors like alcohol intoxication and trauma potentially masking underlying coagulopathies.
Abstract:
Disseminated intravascular coagulation (DIC) is a rare but life-threatening complication encountered in the emergency department (ED). It results from widespread activation of coagulation pathways, leading to simultaneous thrombosis and consumption of clotting factors, often culminating in severe bleeding and multi-organ failure. We report the case of a 39-year-old female with alcohol-related cirrhosis and autoimmune hepatitis who presented to the ED with a minor head injury and active bleeding from a groin ulcer. Her initial evaluation was confounded by alcohol intoxication and suspicion of domestic violence due to multiple bruises. Only after a delayed laboratory assessment was a diagnosis of DIC confirmed in the context of decompensated chronic liver disease with hepatic encephalopathy. She was treated with blood products and discharged with follow-up in the hepatology department. This case illustrates the diagnostic challenges of distinguishing trauma-related bruising from systemic coagulopathy in alcohol-related presentations. It emphasizes the importance of maintaining a high index of suspicion for DIC in cirrhotic patients, the role of the International Society on Thrombosis and Haemostasis DIC score, and the risks of diagnostic overshadowing in the ED. Early recognition and multidisciplinary intervention can significantly improve patient outcomes.
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