Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy
Lingyu Xu1, Stanislau Hrybouski2, Ting-Wei Ernie Liao1
1Cardiovascular Medicine Division (L.X., T.-W.E.L., M.K., D.J.C., F.E.M., S.N.), University of Pennsylvania, Philadelphia.
Insights
Most ventricular tachycardia (VT) corridors in ischemic cardiomyopathy patients are hyperboloid in shape. These viable myocardial pathways, identified using cardiac MRI, show a wider opening at the VT exit than the entrance.
Area of Science:
- Cardiology
- Medical Imaging
- Electrophysiology
Background:
- Ventricular tachycardia (VT) circuitry is often complex in ischemic cardiomyopathy.
- A 3D hyperboloid model has been proposed for VT characterization.
- Geometric features of viable myocardial corridors are crucial for understanding VT.
Purpose of the Study:
- To characterize the geometric features of viable myocardial corridors in ischemic cardiomyopathy.
- To correlate these features with late gadolinium-enhanced cardiovascular magnetic resonance (LGE-CMR) findings.
- To validate LGE-CMR derived geometry with electrophysiological mapping data.
Main Methods:
- Retrospective analysis of 46 ischemic cardiomyopathy patients undergoing LGE-CMR before VT ablation.
- Coregistration of viable corridors on LGE-CMR with VT exit/entrance sites from entrainment/pace mapping.
- Measurement of corridor geometry (hyperboloid, funnel, cylinder), ostium angle, width, length, thickness, volume, and accessibility.
Main Results:
- Of 125 VT exit sites, 93.6% of central corridors were hyperboloid, with 4.8% funnel and 1.6% cylinder.
- All 11 VT entrance sites analyzed showed hyperboloid central corridors.
- The mean VT exit ostium angle (102.8°) was significantly larger than the entrance ostium angle (83.2°).
Conclusions:
- VT corridors in ischemic cardiomyopathy predominantly exhibit hyperboloid geometry.
- Funnel and cylinder geometries are less common but present.
- The hyperboloid shape features a wider opening at the VT exit compared to the entrance, impacting circuit dynamics.
Background:
A 3-dimensional hyperboloid model has been proposed to characterize ventricular tachycardia (VT) circuitry. We sought to characterize the geometric features of viable corridors, derived from late gadolinium enhanced cardiovascular magnetic resonance, that participate in VT circuitry in ischemic cardiomyopathy.
Methods:
In this retrospective cohort study, we analyzed patients with ischemic cardiomyopathy who underwent cardiovascular magnetic resonance before their first VT ablation between November 2018 and May 2024. Viable corridors traversing infarct tissue on late gadolinium enhanced images were coregistered with VT corridor entrance and exit site coordinates, identified by entrainment/pace mapping. The prevalence of VT corridor geometry (hyperboloid, funnel, or cylinder) and corridor ostium angle, width, length, thickness, volume, and accessibility from chambers accessed during the procedure were measured.
Results:
The cohort included 46 patients (95.4% male; 68±8 years of age). Of 125 VT exit sites that registered to a corridor ostium among 45 patients, central corridors predominantly exhibited hyperbola geometry (93.6%), with 4.8% exhibiting funnel and 1.6% exhibiting cylinder geometry. Of 11 VT entrance sites that registered to a corridor ostium among 5 patients, all central corridors exhibited hyperbola geometry. The mean angle of corridor ostium at VT exit was significantly larger than the angle of the opposite ostium (mean±SD, 102.8°±34.1° versus 83.2°±29.5°; P< 0.001).
Conclusions:
Most VT corridors in patients with ischemic cardiomyopathy, derived from late gadolinium enhanced magnetic resonance images and validated by mapping, were hyperboloid, but funnel and cylinder shapes were also seen. The central hyperbola exhibits a larger opening angle at the exit ostium than the entrance.
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