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142
High-Sensitivity C-Reactive Protein and its Association with Diabetic Retinopathy: A Cross-sectional Study.
Zahra Faghih Abdollahi1, Mansour Babaei2, Neda Meftah3
1Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Archives of Iranian Medicine
|October 29, 2025
Summary
High-sensitivity C-reactive protein (hs-CRP) levels correlate with diabetic retinopathy (DR) severity in type 2 diabetes mellitus (T2DM). Elevated hs-CRP indicates increased DR risk and progression, suggesting inflammation
Area of Science:
- Endocrinology
- Ophthalmology
- Inflammation Research
Background:
- Chronic low-grade inflammation is linked to diabetic microvascular complications.
- The association between high-sensitivity C-reactive protein (hs-CRP) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) requires further clarification.
Purpose of the Study:
- To evaluate the independent association between plasma hs-CRP levels and the presence and severity of DR in T2DM patients.
Main Methods:
- An analytical cross-sectional study involving 149 T2DM patients.
- Patients were categorized into no DR, non-proliferative DR (NPDR), and proliferative DR (PDR) groups.
- hs-CRP, HbA1c, fasting blood sugar, and total cholesterol were measured.
Main Results:
- Mean hs-CRP concentrations increased progressively with DR severity (P=0.023).
- Each 1 mg/L increase in hs-CRP was associated with a 1.40-fold higher odds of DR (P=0.011), after adjusting for confounders.
- Independent predictors of DR included longer diabetes duration, higher HbA1c, and female sex.
Conclusions:
- Elevated hs-CRP levels are significantly correlated with DR severity in T2DM patients.
- Inflammation plays a crucial role in the pathogenesis of DR.
- hs-CRP may serve as a potential biomarker for early detection and monitoring of DR.
