Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preparation of Diols and Pinacol Rearrangement01:57

Preparation of Diols and Pinacol Rearrangement

4.1K
Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
4.1K
Structural Isomerism02:34

Structural Isomerism

21.5K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.5K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

10.9K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
10.9K
Stereoisomerism02:52

Stereoisomerism

13.8K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
13.8K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

12.6K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
12.6K
Steady State Concentration01:05

Steady State Concentration

5.8K
A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
Most drugs are administered in repeated doses at fixed intervals or through continuous...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus <i>Pseudoceratina</i>.

Beilstein journal of organic chemistry·2024
Same author

Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation.

Journal of natural medicines·2023
Same author

Zamamiphidins B and C, Manzamine-Related Alkaloids from an <i>Amphimedon</i> sp. Marine Sponge Collected in Okinawa.

Journal of natural products·2022
Same author

Macrocarquinoids A-C, new meroterpenoids from Sargassum macrocarpum.

Journal of natural medicines·2020
Same author

Kamiohnoyneosides A and B, two new polyacetylene glycosides from flowers of edible Chrysanthemum "Kamiohno".

Journal of natural medicines·2020
Same author

Ma'edamines C and D, New Bromotyrosine Alkaloids Possessing a Unique Tetrasubstituted Pyridinium Moiety from an Okinawan Marine Sponge <i>Suberea</i> sp.

Organic letters·2019

Related Experiment Video

Updated: Jan 13, 2026

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

10.0K

Absolute Configuration of Symbiodinolactone A.

Shin-Ichiro Kurimoto1, Kohei Nishie2, Takaaki Kubota1

  • 1Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.

Journal of Natural Products
|October 29, 2025
PubMed
Summary

The absolute configurations of symbiodinolactone A were determined using advanced NMR techniques. This marine macrolide also demonstrated cytotoxicity against leukemia cells.

More Related Videos

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

15.6K
A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids
10:12

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids

Published on: October 13, 2019

9.6K

Related Experiment Videos

Last Updated: Jan 13, 2026

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

10.0K
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

15.6K
A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids
10:12

A Fluorescence-based Assay for Characterization and Quantification of Lipid Droplet Formation in Human Intestinal Organoids

Published on: October 13, 2019

9.6K

Area of Science:

  • Marine Natural Products Chemistry
  • Organic Chemistry
  • Chemical Biology

Background:

  • Symbiodinolactone A is a 12-membered macrolide isolated from marine dinoflagellates.
  • The symbiotic relationship between dinoflagellates and acoelomorphs is a source of novel compounds.
  • Macrolides are known for their diverse biological activities.

Purpose of the Study:

  • To determine the absolute configurations of the five stereogenic centers in symbiodinolactone A.
  • To investigate the cytotoxic potential of symbiodinolactone A.

Main Methods:

  • Utilized Rychnovsky's method for stereochemical determination.
  • Employed Kishi's universal NMR databases and the modified Mosher's method.
  • Analyzed NMR data of a degradation product's bis(S)-MTPA ester against synthesized standards.

Main Results:

  • The absolute configurations were established as 7R,11R,12R,13R,14R.
  • Symbiodinolactone A exhibited cytotoxicity against L1210 murine leukemia cells.
  • The combination of methods provided unambiguous stereochemical assignment.

Conclusions:

  • The complete stereochemistry of symbiodinolactone A has been elucidated.
  • Symbiodinolactone A possesses cytotoxic properties, warranting further investigation for therapeutic potential.
  • This study contributes to the understanding of marine-derived bioactive compounds.