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Updated: Jan 13, 2026
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Risk Factors of Necrotizing Enterocolitis in Neonates With Bloodstream Infections: A Case-Control Study
Chunli Bao1,2, Yue Ma1,2, Jianyu Wang1,2
1Department of Pediatric General Surgery, Women and Children's Hospital, Chongqing Medical University, Chongqing, China.
Objective:
We intend to investigate the risk factors of the necrotizing enterocolitis (NEC)-associated bloodstream infection (BSI) in neonates with NEC.
Methods:
This analysis included a multi-centered retrospective case-control study in 4 newborn intensive care units (NICUs) from 2015 to 2024. The factors involved in the NEC-associated BSI were investigated using univariate and multivariate analyses.
Results:
The majority of NEC-associated BSIs were caused by Klebsiella spp. (23%). Compared with those without BSI, the neonates with BSI had significantly lower gestational age and birth weight (BW), had a higher incidence rate of NEC of stage III (P = .048) and surgical NEC. The independent risk factors of concurrent BSI were BW and first white blood cell (WBC) count. And BSI, vasopressor use at enrollment, and respiratory support were independent risk factors of the NEC-attributable mortality.
Conclusions:
The BSI following NEC was associated with low BW and high WBC, which might be helpful for the optimization of treatment planning.
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