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Proton Beam Therapy in the Oligometastatic/Oligorecurrent Setting: Is There a Role? A Literature Review.

Cancersยท2023
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Related Experiment Video

Updated: Jan 13, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Failure to Complete Proton Beam Therapy Relating to Problems With Anesthesia.

Natalie Blundell1, Love Goyal2,3, Nicola Thorp2

  • 1The Christie NHSFT, Manchester, UK.

Paediatric Anaesthesia
|October 29, 2025
PubMed
Summary

Pediatric proton beam therapy (PBT) requires complex anesthesia, with risks including respiratory events and chemotherapy complications. Careful patient assessment and skilled anesthetic teams are crucial for safe PBT delivery in children.

Keywords:
pediatric anesthesiaproton beam therapyremote site anesthesia

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Area of Science:

  • Pediatric Oncology
  • Radiation Therapy
  • Anesthesiology

Background:

  • Proton beam therapy (PBT) is increasingly used for pediatric cancer.
  • Many children require general anesthesia for precise positioning during PBT.
  • Anesthetic care for PBT is more complex than for X-ray therapy due to patient age and immobilization needs.

Purpose of the Study:

  • To highlight challenges in providing anesthetic care for pediatric PBT.
  • To present a case series of children who failed to complete PBT due to anesthesia-related issues.

Main Methods:

  • Retrospective review of three pediatric patient records.
  • Analysis of cases that failed to complete PBT between January 2020 and December 2022.

Main Results:

  • Two of three patients failed PBT due to respiratory adverse events, one requiring intensive care.
  • Both patients with respiratory events had central nervous system tumors.
  • The third patient developed neutropenic typhlitis from chemotherapy, precluding further anesthesia.

Conclusions:

  • Adverse event risk in pediatric PBT patients can be unpredictable.
  • Thorough pre-anesthetic assessment, including regular blood tests and infection screening, is essential.
  • Highly skilled anesthetic teams familiar with PBT environments are necessary for safe care.