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Pitfalls in the Serologic Diagnosis of Maternal Syphilis: A Case Series

Sameer B Chand1, Traci Pifer2, Sebastian Martinez2

  • 1From the The Ohio State University.

Sexually Transmitted Diseases
|October 29, 2025
PubMed

Pregnancy is associated with false-positive treponemal and nontreponemal screening test results. We present 5 pregnant women who had reactive treponemal screening and nontreponemal test results but nonreactive Treponema pallidum- particle agglutination test result. Reliance on treponemal screening tests may result in misdiagnosis and unnecessary treatment, unless a specific treponemal test is performed.

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