Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Nucleic acids02:43

Nucleic acids

188.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
188.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal-Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids.

Angewandte Chemie (International ed. in English)·2026
Same author

Correction to "DNA-Mediated Cellular Delivery of Functional Enzymes".

Journal of the American Chemical Society·2026
Same author

High-χ Block Copolymer Nanoreactors for the Confined Synthesis of Size-Controlled Nanoclusters.

ACS nano·2026
Same author

Programmable Stepwise Heteroepitaxial Growth of Colloidal Crystals With Different Phases.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Simplex-based model for nanoparticle grain identification in four-dimensional scanning transmission electron microscopy data.

Journal of microscopy·2026
Same author

Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions.

Biomaterials science·2026
Same journal

A pH-Tolerant Nickel-Vanadium Phosphonate Framework for Stable Aqueous Supercapacitor Cycling.

ACS nano·2026
Same journal

Reconfigurable Photoelectric Coaxial Fiber-Based Memristors for Neuromorphic Computing.

ACS nano·2026
Same journal

Multidimensional Emission Control of CsPbI<sub>3</sub> Quantum Dots Using Plasmonic Quasi-Bound States in the Continuum.

ACS nano·2026
Same journal

Reconfigurable 2D Floating-Gate Field-Effect Transistors with Graphene-Induced Interfacial Polarization for Unified Memory-Logic Integration.

ACS nano·2026
Same journal

Bioinstructive Hybrid Scaffold Integrating Phosphoinositide 3-Kinase-Akt and Complementary Survival Pathways for Kidney Regeneration.

ACS nano·2026
Same journal

Robust Quantum Cutting via Halide-Bearing Ligand Passivation and Gradient Halide Reconstruction for Ultrabroadband Ultraviolet-to-Near-Infrared Photodetection and Imaging.

ACS nano·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.9K

Chemotherapeutic Spherical Nucleic Acids.

Taokun Luo1,2, Young Jun Kim3,2, Zhenyu Han1,2

  • 1Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

ACS Nano
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Spherical nucleic acid (SNA) constructs carrying 5-fluorouracil (5-Fu) demonstrate enhanced uptake by acute myeloid leukemia (AML) cells. This novel nanomedicine approach significantly improves chemotherapeutic delivery and efficacy against AML.

Keywords:
cancerchemotherapyleukemiananomedicineoligonucleotidespherical nucleic acid

More Related Videos

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.5K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.4K

Related Experiment Videos

Last Updated: Jan 6, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.9K
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.5K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.4K

Area of Science:

  • Nanomedicine
  • Molecular Biology
  • Oncology

Background:

  • Conventional small-molecule drugs like 5-fluorouracil (5-Fu) face challenges in targeted delivery and cellular uptake.
  • Liposomal drug delivery systems improve drug solubility and circulation time but often lack specific cellular targeting.
  • Acute myeloid leukemia (AML) remains a significant challenge, necessitating innovative therapeutic strategies.

Purpose of the Study:

  • To design and synthesize liposomal spherical nucleic acid (SNA) constructs incorporating 5-fluorouracil (5-Fu).
  • To evaluate the cellular uptake, chemotherapeutic efficacy, and in vivo antitumor activity of these 5-Fu-SNAs in AML models.
  • To investigate the impact of SNA structure on chemotherapeutic delivery and cell targeting.

Main Methods:

  • Synthesis of liposomal SNA constructs with phospholipid cores and 5-fluoro-2'-deoxyuridine oligonucleotides.
  • Modification of oligonucleotides with hexaethylene glycol and cholesterol end groups for liposomal anchoring.
  • In vitro assessment of cellular uptake and cytotoxicity compared to free 5-Fu.
  • In vivo evaluation of antitumor efficacy and hematological markers in a human AML mouse model.

Main Results:

  • 5-Fu-SNAs exhibited up to 12.5-fold increased cellular uptake by myeloid and AML cells compared to conventional 5-Fu.
  • In vitro studies showed up to 4 orders of magnitude enhancement in cell killing with 5-Fu-SNAs.
  • In vivo studies demonstrated 59-fold superior antitumor efficacy of 5-Fu-SNAs in an AML mouse model with improved hematological markers and no observable side effects.

Conclusions:

  • Liposomal SNA constructs represent a potent platform for chemotherapeutic delivery, significantly enhancing potency and targeting.
  • Restructuring chemotherapeutics into SNAs overcomes limitations of conventional small-molecule drug delivery.
  • This nanomedicine strategy offers a promising approach for improved AML treatment with enhanced efficacy and safety.