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Related Experiment Video

Updated: Jan 6, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Atrial Fibrillation Screening According to Genetic Risk: A Secondary Analysis of the Randomized LOOP Study.

Oliver B Vad1, Søren Z Diederichsen2, Lucas Y Xing2

  • 1Department of Cardiology, the Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Journal of the American College of Cardiology
|October 29, 2025
PubMed
Summary

Polygenic risk scores (PRS) can identify individuals who benefit from atrial fibrillation (AF) screening. Implantable loop recorder (ILR) screening reduced stroke/systemic embolism (SE) in those with high PRS-AF, but not low PRS-AF.

Keywords:
PRSatrial fibrillationgeneticsscreeningstroke

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Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Preventive Cardiology

Background:

  • Polygenic risk scores (PRS) are emerging tools for cardiovascular disease risk stratification.
  • Atrial fibrillation (AF) screening aims to prevent stroke and systemic embolism (SE).

Purpose of the Study:

  • To evaluate the effectiveness of AF screening using an implantable loop recorder (ILR) for stroke prevention in relation to a polygenic risk score for AF (PRS_AF).

Main Methods:

  • A post hoc analysis of the randomized LOOP study included 5,656 AF-naive individuals (≥70 years) with stroke risk factors.
  • Participants were randomized to ILR screening or usual care.
  • Cause-specific Cox regressions assessed interactions between ILR screening and PRS_AF for stroke/SE and major bleeding.

Main Results:

  • Higher PRS_AF was associated with increased AF rates (HR: 1.20).
  • ILR screening significantly reduced stroke/SE in individuals with PRS_AF ≥median (HR: 0.65), but not in those with PRS_AF
  • ILR screening increased major bleeding risk in those with PRS_AF

Conclusions:

  • AF screening via ILR effectively reduced stroke/SE in individuals with high genetic predisposition (high PRS_AF).
  • These findings suggest PRS may help personalize AF screening strategies for optimal stroke prevention.