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Updated: Jan 6, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electrochemical Cp2Fe-Catalyzed Diazidation of Alkenes
Jiankun Chen1,2, Fanhua Meng2, Qiaoyu Gan2
1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, China.
Abstract:
A safe, effective, and eco-friendly electrochemical method for diazidating alkenes with TMSN3 was created, which can be carried out smoothly with Cp2Fe as the catalyst, affording a series of vicinal diazide products with excellent substrate scope compatibility. The late-stage functionalization of biologically active compounds, half-gram-scale experiments, and synthetic transformations additionally highlight the synthetic potential of this protocol. Moreover, mechanism studies show that Cp2Fe was oxidized by the anode and then promoted the single electron transfer of N3- to release the azidyl radical (N3●).
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