Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

18.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.6K
Cell Migration01:19

Cell Migration

6.4K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.4K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.2K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.2K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.2K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

6.5K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-view deep learning of highly multiplexed imaging data improves association of cell states with clinical outcomes.

Bioinformatics advances·2026
Same author

GSK3β-Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.

Cell reports·2025
Same author

GSK3β Deficiency Expands Obese Adipose Vasculature to Mitigate Metabolic Disorders.

Circulation research·2024
Same author

PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

Natural compound screening predicts novel GSK-3 isoform-specific inhibitors.

Biochimie·2024

Related Experiment Video

Updated: Jan 13, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

140.9K

Akt/PKB Functions in Cell Migration and Invasion.

Jennifer L Gorman1, James R Woodgett2,3

  • 1Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.

Current Topics in Microbiology and Immunology
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

The protein-serine kinase Akt/PKB plays a dual role in cell migration, either promoting or inhibiting movement based on cellular context. Understanding Akt/PKB

More Related Videos

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.8K
Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
10:43

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration

Published on: May 19, 2016

7.0K

Related Experiment Videos

Last Updated: Jan 13, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

140.9K
Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.8K
Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
10:43

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration

Published on: May 19, 2016

7.0K

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Cell migration is a complex, regulated process essential for normal physiology and implicated in diseases like cancer metastasis.
  • The phosphatidylinositol 3' kinase (PI3K)/Akt pathway is a key signaling cascade involved in various cellular functions, including migration.

Purpose of the Study:

  • To elucidate the intricate and context-dependent role of the protein-serine kinase Akt/PKB in regulating cell migration.
  • To review Akt/PKB targets involved in cellular movement and discuss their implications for controlling cancer dissemination.

Main Methods:

  • Review of molecular events governing cell migration.
  • Analysis of current knowledge regarding Akt/PKB targets in cell movement.
  • Discussion of the implications of Akt/PKB modulation for cancer metastasis.

Main Results:

  • Akt/PKB's function in cell migration is context-dependent, acting as either a promoter or inhibitor of movement.
  • The net effect of Akt/PKB modulation relies on cellular context and other signaling inputs.
  • Perturbations disrupting migratory machinery are inhibitory, while enhanced coordination increases mobility.

Conclusions:

  • Akt/PKB's dual role in cell migration necessitates a nuanced understanding of its regulatory mechanisms.
  • Targeting Akt/PKB signaling pathways holds potential for developing strategies to suppress cancer metastasis.