Transcriptomics empower assisted reproductive technology in decoding gamete and embryo development potential: a...

Area of Science:

• Reproductive biology
• Genomics
• Assisted Reproductive Technologies (ART)

Background:

• Transcriptomics offers insights into gene expression and regulatory networks.
• Understanding germ cell and early embryo transcriptomes is key for ART.
• Current knowledge on transcriptomic profiles in reproduction requires synthesis.

Purpose of the Study:

• To review transcriptomic profiles of germ cells and early embryos.
• To elucidate molecular signatures related to developmental potential and embryo quality.
• To demonstrate transcriptomics applications in preimplantation genetic testing (PGT) and in vitro culture optimization.

Main Methods:

• Literature review of transcriptomic studies in reproductive biology.
• Analysis of key molecular signatures in germ cells and embryos.
• Evaluation of transcriptomics in PGT and in vitro culture optimization.

Main Results:

• Transcriptomics identifies molecular signatures for developmental potential, maturation, and embryo quality.
• Transcriptomic data enhances precision in PGT for chromosomal abnormalities and genetic disorders.
• Transcriptomic approaches aid in evaluating embryonic potential and optimizing culture conditions.

Conclusions:

• Transcriptomics is crucial for advancing assisted reproductive technologies.
• Applications in PGT and culture optimization improve ART success rates.
• Transcriptomic insights support personalized treatment strategies in ART.