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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

333
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
333
Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

862
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

298
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
298

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Related Experiment Video

Updated: Jan 13, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

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Published on: April 27, 2015

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[Update: Organ Donation and Preservation].

Gyoergy Lang1,2, Christian Lang3

  • 1Klinik für Thoraxchirurgie, UniversitätsSpital Zürich, Zürich, Schweiz.

Zentralblatt Fur Chirurgie
|October 29, 2025
PubMed
Summary

Innovations in organ donation, including normothermic ex vivo lung perfusion (EVLP) and donation after circulatory death (DCD), are expanding the donor pool and improving lung transplantation outcomes. Controlled hypothermic preservation also enhances logistical flexibility.

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Last Updated: Jan 13, 2026

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Area of Science:

  • Cardiovascular & Pulmonary Medicine
  • Transplantation Biology
  • Surgical Innovation

Background:

  • Lung transplantation faces challenges due to donor lung shortages and preservation limitations.
  • Advancements in organ preservation and donation strategies are crucial for improving patient outcomes.
  • Marginal donor lungs and extended preservation times remain significant areas for research.

Purpose of the Study:

  • To review recent innovations in organ donation and donor lung preservation.
  • To highlight the impact of normothermic ex vivo lung perfusion (EVLP), donation after circulatory death (DCD), and hypothermic preservation on lung transplantation.
  • To summarize the current state of knowledge on optimizing donor lung utilization and viability.

Main Methods:

  • Review of key advancements in lung transplantation technologies and strategies.
  • Analysis of the role of normothermic ex vivo lung perfusion (EVLP) in donor lung assessment and rehabilitation.
  • Examination of donation after circulatory death (DCD) protocols and outcomes.
  • Evaluation of controlled hypothermic preservation at 10°C for extended lung viability.

Main Results:

  • Normothermic ex vivo lung perfusion (EVLP) enables the use of high-risk donor lungs, improving transplantation outcomes.
  • Donation after circulatory death (DCD) provides a comparable alternative to traditional donation, addressing donor shortages.
  • Controlled hypothermic preservation at 10°C extends preservation times and offers greater scheduling flexibility.

Conclusions:

  • EVLP, DCD, and controlled hypothermic preservation represent significant progress in lung donation and preservation.
  • These innovations expand the donor pool and enhance the feasibility and success of lung transplantation.
  • Future research and clinical integration of these techniques are expected to further revolutionize lung transplantation standards.