Chromosome heteromorphisms: Critical literature review finds No convincing evidence of harm

There are conflicting reports on chromosome heteromorphisms. A large number of papers claim that these variants are found more frequently among infertile couples, especially with recurrent pregnancy loss and are even associated with congenital abnormalities. Other studies have found no evidence to support such claims. A critical review of these papers shows that at present there is no convincing evidence to show that heteromorphic chromosome variants, as described in the International System for Human Cytogenomic Nomenclature (ISCN, 2024), are harmful.