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Updated: Jan 13, 2026
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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
893
Gene Expression Profiling (GEP) in Dermatology, Part 1: Introduction, Development, Benefits, Limitations, and Future
Sino Mehrmal1, Marcus G Tan2, Sarah T Arron3
1Division of Dermatology, Baylor University Medical Center, Dallas, TX.
Journal of the American Academy of Dermatology
|October 29, 2025
Summary
Gene expression profiling (GEP) offers molecular insights for diagnosing skin conditions. This technology analyzes messenger RNA to guide treatment decisions in dermatology.
Area of Science:
- Dermatology and Molecular Biology
Background:
- Gene expression profiling (GEP) provides molecular insights for skin cancer and inflammatory dermatoses.
- It complements traditional diagnostic methods in dermatology.
Purpose of the Study:
- To highlight the impact and development of GEP in dermatology.
- To discuss the potential of GEP in personalized patient care.
Main Methods:
- GEP evaluates messenger RNA (mRNA) levels.
- Disease-specific expression patterns are identified.
- Test development involves discovery, validation, and clinical implementation.
Main Results:
- Commercially available GEP tests exist for melanoma and cutaneous squamous cell carcinoma.
- GEP aids in diagnosis, prognostication, and treatment planning.
Conclusions:
- GEP is advancing personalized dermatology.
- Further prospective studies and cost considerations are needed.
- GEP holds promise for improved patient care in dermatological conditions.
Keywords:
Kawasaki diseaseRNA sequencingalopecia areataartificial intelligenceatopic dermatitiscontinuing medical educationcutaneous T-cell lymphomacutaneous oncologydermatologydiagnosticsgene expression profilelymph nodemachine learningmelanomametastaticmicroarraymolecular diagnosticspolymerase chain reactionprecision medicineprognosticspsoriasisrisk stratificationskin cancersquamous cell carcinoma
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