Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoxia01:23

Hypoxia

1.9K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.9K
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

5.9K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
5.9K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

1.0K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.0K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

580
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
580
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating current bronchiectasis care in Italy according to the 2025 European respiratory society recommendations.

Therapeutic advances in respiratory disease·2026
Same author

The Digital Mirror: Clinical Potentials and Relational Risks of Generative AI in Mental Health Interventions.

Current psychiatry reports·2026
Same author

Author Correction: Unexpected events and prosocial behavior: the Batman effect.

Npj mental health research·2026
Same author

Transdiagnostic psychological processes underlying anxiety, depression, alcohol use disorder, and problematic social media use: A Bayesian RDoC-informed study.

Behaviour research and therapy·2026
Same author

Personality in pulmonary rehabilitation: why dispositions matter more than cut-offs.

ERJ open research·2026
Same author

Breathing Under Pressure: Psychological Burden and Recovery Trajectories in Patients Receiving Non-Invasive Respiratory Support from Acute COVID-19 to Respiratory Rehabilitation.

Medical sciences (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 13, 2026

Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

86.2K

Hypoxia.

Diletta Barbiani1, Eleonora Volpato2, Francesco Pagnini1

  • 1Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.

Handbook of Clinical Neurology
|October 29, 2025
PubMed
Summary
This summary is machine-generated.

Placebo and nocebo effects significantly impact hypoxia research. Understanding these psychological influences can improve oxygen utilization and symptom management in patients with respiratory diseases.

Keywords:
Cognitive processExpectationsHigh-altitudeHypoxiaMedicineNocebo effectOxygenPlacebo effectRespiratory diseasesRespiratory findingRespiratory functionTherapeutic procedure

More Related Videos

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

3.7K
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

18.7K

Related Experiment Videos

Last Updated: Jan 13, 2026

Induction and Testing of Hypoxia in Cell Culture
07:01

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

86.2K
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

3.7K
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

18.7K

Area of Science:

  • Physiology
  • Psychology
  • Altitude Research

Background:

  • Placebo and nocebo effects are crucial in hypoxia research, particularly in high-altitude environments.
  • These effects can influence vital functions like ventilation, circulation, and performance under oxygen deprivation.
  • The brain's influence on physiology is evident even when survival is threatened.

Purpose of the Study:

  • To explore the role of placebo and nocebo effects in hypoxia.
  • To investigate the potential application of this knowledge in treating respiratory diseases.
  • To enhance the management of hypoxic patients and optimize oxygen utilization strategies.

Main Methods:

  • Review of studies on placebo and nocebo effects in high-altitude environments.
  • Analysis of how psychological factors influence physiological responses to hypoxia.
  • Examination of evidence linking beliefs and expectations to oxygen deprivation responses in respiratory patients.

Main Results:

  • Placebos can partially mimic oxygen's effects and compensate for imbalances during hypoxia.
  • Nocebos can worsen hypoxia symptoms, demonstrating the brain's physiological influence.
  • Psychological aspects are as critical as physiological factors in respiratory disease management.

Conclusions:

  • Knowledge of placebo and nocebo effects in natural hypoxia can improve patient management.
  • Incorporating psychological insights can optimize oxygen utilization and symptom control.
  • Beliefs and expectations play a significant role in how patients with respiratory diseases respond to oxygen deprivation.