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Guillain-Barré Syndrome and Variants
Long Davalos1, John T Kissel2, Richard J Barohn3
1The University of Kansas Medical Center, Kansas City, KS, USA; Neuromuscular Division, Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Boulevard, Kansas City, KS 66160, USA.
None:
Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy that leads to rapidly progressive weakness and, in up to 20% of cases, respiratory failure. GBS is a heterogeneous disorder with varying phenotypic presentations, electrophysiologic features, and outcomes. Plasma exchange and intravenous immunoglobulin can help reduce the time to recovery, in addition to improving ventilatory function and mobility. New treatments, such as C1q complement-blocking antibodies, are currently under study and may improve outcomes in the future. This article provides an overview of the epidemiology, clinical symptoms, causes, diagnostic methods, treatment options, and prognosis of GBS.
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