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Related Experiment Video

Updated: Jan 13, 2026

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Experience-Dependent Plasticity to Visual Sequences in Mouse Anterior Cingulate Cortex Reflects Familiarity.

Ayse Malci1, Daniel P Montgomery1, Nishitha S Hosamane1

  • 1Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|October 29, 2025
PubMed
Summary

The anterior cingulate cortex (ACC) adapts to familiar visual stimuli through stimulus-specific response plasticity in timing (SRPT). Angelman syndrome model mice show impaired ACC responses to familiar visual cues.

Keywords:
Angelman syndromeanterior cingulate cortexexperience-dependent plasticityvisual system

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • The anterior cingulate cortex (ACC) is crucial for cognitive control, attention, and prediction.
  • Mouse ACC integrates visual information for behavioral guidance.
  • Experience-dependent plasticity in ACC's visual processing remains less understood compared to V1.

Purpose of the Study:

  • To investigate whether ACC plasticity to visual sequences reflects stimulus familiarity or expectation.
  • To characterize the nature of experience-dependent plasticity in mouse ACC.
  • To examine ACC function in a mouse model of Angelman syndrome (AS).

Main Methods:

  • Recorded visually evoked responses in awake, head-fixed mice (male and female) trained with visual sequences.
  • Utilized single-orientation stimuli to test plasticity induction.
  • Compared ACC and V1 plasticity in AS model mice versus controls.

Main Results:

  • Visual sequences induced plasticity in ACC, altering response timing based on familiarity with the initial stimulus.
  • Plasticity could be induced even with single-orientation stimuli, suggesting a broader phenomenon.
  • AS model mice exhibited abnormal ACC responses to familiar visual stimuli, contrasting with normal V1 plasticity.

Conclusions:

  • ACC plasticity to visual stimuli is stimulus-specific, termed stimulus-specific response plasticity in timing (SRPT), and does not strictly require sequences.
  • This study elucidates how mouse ACC adapts to familiar visual information.
  • Impaired ACC function in AS model mice highlights its role in neurodevelopmental disorders.