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Updated: May 5, 2026
High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
Published on: July 25, 2015
Dual-Vessel Microcirculation Imaging in Discriminating Non-Hodgkin Lymphoma Subtypes Using Super-Resolution
YiJie Dong1, Qing Hua2, ShuJun Xia2
1Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, China 200025 (Y.D., Q.H., S.X., C.Y., Y.Z., R.T., Z.L., J.Z.); College of Health Science and Technology，Shanghai JiaoTong University School of Medicine, Shanghai, China 200025 (Y.D., J.Z.).
Background:
Identifying the subtype of intranodal non-Hodgkin lymphoma (NHL) is crucial for clinical management.
Rationale And Objectives:
To display dual-vessel systems (microvascular and microlymphatic circulation) of intranodal NHL using super-resolution ultrasound (SRUS), and explore the diagnostic performance of SRUS imaging for predicting B-cell and T-cell subtypes NHL.
Materials And Methods:
A total of 49 patients with intranodal NHL underwent dual-vessel system SRUS imaging via intravenous and intra-lymph node routes. Least absolute shrinkage and selection operator (LASSO) regression, fitted the LASSO model and leave-one-out cross-validation (LOOCV) were used for model development and internal validation.
Results:
Among the 49 patients, 40 were diagnosed with B-cell NHL and 9 with T-cell NHL. Variables including LDmax, LDLmin, and VCmin were selected and the logistic regression model achieved discrimination of B-cell and T-cell subtype of lymphoma with an AUC of 0.831 (0.594-0.969).
Conclusion:
Dual-vessel SRUS imaging can display real time microvascular and microlymphatic circulation of intranodal NHL in physiological status. With quantitative analysis of SRUS offers a potential non-invasive diagnostic alternative in differentiating NHL subtype.
