Enzyme-HOF Hybrid Particles Composite Hydrogel Dressing for Diabetic Wound Healing

Area of Science:

• Biomaterials Science
• Wound Healing Research
• Nanotechnology

Background:

• Diabetic wounds (DWs) present significant healing challenges due to hyperglycemia, infection, and altered pH.
• Conventional treatments for DWs, including antibiotics and debridement, have limitations like drug resistance and high costs.

Purpose of the Study:

• To develop a novel hybrid particle and composite hydrogel for enhanced diabetic wound healing.
• To immobilize glucose oxidase (GOx) within a hydrogen-bonded organic framework (HOF-101) for sustained enzymatic activity.

Main Methods:

• In situ encapsulation of GOx in HOF-101 via hydrogen bonding-triggered self-assembly.
• Formation of hybrid particles with polydopamine coating and incorporation into a dual-network hydrogel.
• Evaluation of pH reduction, hydrogen peroxide generation, photothermal response, and antibacterial efficacy.

Main Results:

• The composite hydrogel effectively consumes glucose, reducing local pH and generating hydrogen peroxide.
• Tunable photothermal properties under near-infrared (NIR) irradiation were achieved for microenvironment modulation.
• Synergistic antibacterial effects and favorable mechanical properties and biocompatibility were demonstrated.

Conclusions:

• The developed composite hydrogel shows significant potential for treating diabetic wounds.
• This innovative approach offers a promising alternative to traditional treatments by addressing key challenges in diabetic wound healing.